https://www.sciencedirect.com/science/ar...7722000822
1.
Insufficient BH4 leads to the uncoupling of the inducible Nitric Oxide Synthase (iNOS) and thereby initiates self-perpetuating oxidative stress with excess superoxide and peroxynitrite.
2.
Insufficient BH4 impedes and may even prevent the downregulation of this hyperinflammatory oxidative stress and the return to oxidative homeostasis.
5.
Restore oxidative balance through the supplemental provision of antioxidants:
6.
- vitamins C, D3, E (mixed tocopherols; especially gamma tocopherol)
- balanced diet with fresh vegetables and fruit
- OTC antioxidants: superoxide dismutase, catalase, alpha-lipoic acid, CoQ-10,
melatonin, glutathione (liposomal or sublingual spray; or N-acetyl-cystine and glycine)
-prescribe tramadol to increase superoxide dismutase and glutathione peroxidase [39]
7.
Supplement with quercetin and resveratrol (which are also antioxidants) to stimulate immune regulators to downregulate iNOS [40], [41], [42], [43], [44], [45].
8.
Restore methylation cycle with l-methylfolate and hydroxycobalamin (B12) to increase BH4 through de novo production and recycling.
9.
Control or reduce other sources of oxidative stress (allergens, mold, smoking, and volatile organic chemicals) that increase superoxide.
10.
Provide sufficient exogenous BH4 to recouple all three forms of NOS (eNOS, iNOS, nNOS) by supplementing with Pteridin-4 (OTC form of sapropterin, 2.5 mg) or by prescribing low dose Kuvan (sapropterin) in powder form.
Witaminę D, cysteinę i glicynę biorę od dwóch lat, moja dieta to tylko zdrowe warzywa i orzechy, mięso, a dalej jestem chory, wiec nie wiem, czy ma to sens?
1.
Insufficient BH4 leads to the uncoupling of the inducible Nitric Oxide Synthase (iNOS) and thereby initiates self-perpetuating oxidative stress with excess superoxide and peroxynitrite.
2.
Insufficient BH4 impedes and may even prevent the downregulation of this hyperinflammatory oxidative stress and the return to oxidative homeostasis.
5.
Restore oxidative balance through the supplemental provision of antioxidants:
6.
- vitamins C, D3, E (mixed tocopherols; especially gamma tocopherol)
- balanced diet with fresh vegetables and fruit
- OTC antioxidants: superoxide dismutase, catalase, alpha-lipoic acid, CoQ-10,
melatonin, glutathione (liposomal or sublingual spray; or N-acetyl-cystine and glycine)
-prescribe tramadol to increase superoxide dismutase and glutathione peroxidase [39]
7.
Supplement with quercetin and resveratrol (which are also antioxidants) to stimulate immune regulators to downregulate iNOS [40], [41], [42], [43], [44], [45].
8.
Restore methylation cycle with l-methylfolate and hydroxycobalamin (B12) to increase BH4 through de novo production and recycling.
9.
Control or reduce other sources of oxidative stress (allergens, mold, smoking, and volatile organic chemicals) that increase superoxide.
10.
Provide sufficient exogenous BH4 to recouple all three forms of NOS (eNOS, iNOS, nNOS) by supplementing with Pteridin-4 (OTC form of sapropterin, 2.5 mg) or by prescribing low dose Kuvan (sapropterin) in powder form.
Witaminę D, cysteinę i glicynę biorę od dwóch lat, moja dieta to tylko zdrowe warzywa i orzechy, mięso, a dalej jestem chory, wiec nie wiem, czy ma to sens?