12-04-2021, 10:04 PM
https://www.nature.com/articles/s41392-021-00749-3
In our study, among the altered metabolites in the analysis of serum metabolite profiles, the levels of the amino acids l-arginine, l-glutamic acid, l-isoleucine, l-cystine, and l-cysteine were significantly reduced in the serum from recovered COVID-19 patients. These results indicate that the disrupted metabolism may affect B-cell activation and function in recovered patients
In our study, ROS was found to increase and CD19 expression was decreased, and interestingly, CD19 expression and BCR signaling was rescued partially in recovered patients by using ROS scavenger-NAC.
If it is true, the metabolism regulator such as NAC may have a potential clinical application on the prevention of second infection of recovered patients.
In our study, among the altered metabolites in the analysis of serum metabolite profiles, the levels of the amino acids l-arginine, l-glutamic acid, l-isoleucine, l-cystine, and l-cysteine were significantly reduced in the serum from recovered COVID-19 patients. These results indicate that the disrupted metabolism may affect B-cell activation and function in recovered patients
In our study, ROS was found to increase and CD19 expression was decreased, and interestingly, CD19 expression and BCR signaling was rescued partially in recovered patients by using ROS scavenger-NAC.
If it is true, the metabolism regulator such as NAC may have a potential clinical application on the prevention of second infection of recovered patients.