12-09-2025, 01:01 AM
Jak się okazuje, jest więcej doniesień na temat niskich dawek klonazepamu. Tu artykuł z Nature z 2012 roku:
https://www.nature.com/articles/nature11356
https://www.nature.com/articles/nature11356
Cytat:Remarkably, treatment with low-dose clonazepam, a positive allosteric modulator of GABAA receptors, completely rescued the abnormal social behaviours and deficits in fear memory in the mouse model of Dravet’s syndrome, demonstrating that they are caused by impaired GABAergic neurotransmission and not by neuronal damage from recurrent seizures. These results demonstrate a critical role for NaV1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet’s syndrome.



